Sunday, August 22, 2010

FOLKMAN'S WAR

Dr. Judah Folkman fought a long battle with a medical community that didn't believe in the idea solid tumors could secret chemicals in order to establish their own blood supply. His steadfast work in the face of adversity hearld the dawning of a new era and greater understanding of how cancer cells ensure their development and survival.
http://www.pbs.org/wgbh/nova/cancer/
The processes required for a normal cell to transform into a cancer cell include the ability to master self sufficiency in growth signals, ensuring that the cell maintains an insensitivity to antigrowth signals, evasion of the cell's encoded programmed death, continued replication and metastasis, and most importantly ensuring a steady blood supply or angiogenesis.
Cancer caught on video: http://www.pbs.org/wgbh/nova/cancer/cells.html
Through Folkman's work, science has discovered a way in which to cut off the newly formed blood supply to these rogue cells, breaking the cycle established for their continued survival. For a more detailed look at Dr. Folkman's work read the article in the July/August 2010 edition of Cancer Journal for Clinicians:
http://caonline.amcancersoc.org/cgi/content/full/60/4/222
And for a closer look at Dr. Folkman's life and achievements:
http://www.amazon.com/Dr-Folkmans-War-Angiogenesis-Struggle/dp/0375502440/ref=sr_1_1?ie=UTF8&s=books&qid=1282485925&sr=8-1

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